Sarah will be back in front of the camera again, this time for director Vincenzo Natali in what was–initially–going to be a follow-up to his 1997 film Cube: a sci-fi film entitled Splice. She and Adrien Brody will portray scientists who become well-known for their work in genetic engineering–in particular, splicing animal DNA to create new creatures.
Filming for the Canada/France co-production is to begin in Toronto in early December, with production to wrap in February 2008.

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